Home  |   ENM 1.0  |   Tutorials  |   Theory  |   References  |   iGNM 2.0  |   ANM 2.0  |   Computational Biology  |   PITT site

Welcome to DynOmics Portal for computing and visualizing biomolecular systems dynamics!
Below is a roadmap for using the different components of our portal. ENM 1.0 provides a unifying user-friendly interface for efficiently performing a broad range of computations by biologists.

Server for all GNM + ANM computations, for evaluating the changes in dynamics in the presence of environment, and for identifying potential functional sites, e.g. key mechanical residues, residues acting as sensors and effectors derived from perturbation response analysis, residues, signaling sites potentially involved in allosteric communication, construction of all atom conformers along ANM modes, animations

Database of GNM dynamics pre-computed for all PDB structures (data on mean-square fluctuations, B-factors, domain separations, correlations between domain movements for biological assemblies)

API for analyzing the structure-based dynamics of biomolecular systems, including the ensemble and/or family properties of sets of conformers or structural homologs, and conformational sampling using elastic network models (ANM and GNM), bridging with sequence conservation and evolution and target druggability

Server for visualizing and downloading animations of collective modes, movies, inter-node distance fluctuations, correlations, deformation energy, based on anisotropic network model