Bahaar Lab title bar

corner graphic Current/Recent Projects          
Grants

Active

Project title Role Project Dates Funding Source
Structure and Function of PTH class B GPCR (PIs: Jean-Pierre Vilardaga (Pitt)* and I Bahar) MPI 04/27/2023-
03/31/2027
NIH-NIDDK R01 DK116780-05
Toward a deeper understanding of allostery and allotargeting by computational approaches MPI (Bahar* and Doruker) PI (joint with Doruker) 2025-2026 NIH-NIGMS R01
Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis (PI: Bayir) Co-I 2020-2025 NAIAD UO1
Targeting glycosylation of B7-H4 in breast cancer therapy (PI: Yong Wang, Emory) Co-I 2021-2026 NCI R01
Targeting posttranslational modifications of CD73 in TNBCs (PI: Yong Wang, Emory) Co-I 2021-2026 NCI R01
Druggable Mitochondrial Targets for Treatment of Cerebral Ischemia (PIs: Clark and Bayir, UPMC) co-investigator 2020-2025 NIH-NINDS R01

Recently Completed

Project title Role Project Dates Funding Source
Towards Establishing a Center for High Throughput Structure-Based Drug Discovery (SBU-DD) (PI: Markus Seeliger), in collaboration with Brookhaven National Lab Co-I 07/01/2023-
12/31/2024
Biomedical Science Innovation Seed Grant, OVPR- Stony Brook U
Interactions between a novel cancer target and inhibitors (PI: Ivet Bahar in collaboration with Shardule Shah at Lime Therapeutics) PI 07/01/2023-
07/15/2024
ARAD Program of Center for Biotech (NYSTAR) & Lime Therapeutics
The mechanism of allosteric modulation of glutamate transporters (PI: A Mortensen and Olga Boudker) Co-I 2020-2024 NINDS R01
Identification of genetic factors and novel compounds for alleviating jet lag (PI: Stephen Chang, UPMC) Co-I 2021-2024 Greater Houston Comm
Immunosuppression in Acute Lung Injury (PI: Mallampalli, Ohio State U) co-investigator 2019-2024 NIH-NHLBI P01 HL114453
New Therapies for Liver Fibrosis and Hyperproliferation in a1-AT Deficiency (PI: Perlmutter, Wash U) PI of Comp Pharmacology Core 2012-2024 NIH-NIDDK P01 DK96990
Integrated, Interdisciplinary, Comprehensive Inter-University Ph.D. Program in Comp Biol. PIs: Faeder* and Bahar (Pitt), and Bar-Joseph and Russell (CMU) MPI (Faeder* and Bahar (Pitt); Bar-Joseph and Russell (CMU)) 2009-2024 NIH-NIBIB T32 EB009403
Computer-aided discovery and development of drugs against rare diseases PI 2021-2023 Congruence, Inc.
Biological Springs as Allosteric Modulators (MPI: Itzhaki (Cambridge, UK), Gordon (Victoria U, Canada), Yang (Tsinghua U, Taiwan), and Bahar (Pitt) MPI 2020-2023 HFSP
BTRC on High Performance Computing for Multiscale Modeling of Biological Systems (MMBioS) (PI: Bahar) PI (2012-2021) TDP Leader (2021-2023) 2012-2023 NIH-NIGMS P41 GM103712
Controlling Monolysocardiolipin/cytochrome c Peroxidase Complexes in Barth Syndrome (PI's: Greenberg (Wayne State) and Kagan (Pitt)) co-investigator 2020-2022 NIH-NIGMS R01
Allosteric modulation of dopamine transport-Functional and Biochemical Studies (PI: Ole Mortensen, Drexel University) co-investigator 2020-2022 NIH R01
Identification of drug candidates for PTHR (PIs: Bahar and Vilardaga, Pitt) MPI (Bahar* and Vilardaga) 2019-2020 NIH-CTSI Pilot UL1TR001857
NIDA Center of Excellence for Computational Drug Abuse Research (CDAR) (PIs: Xie* (Pitt), Bahar (Pitt) and Xing- Carnegie Mellon University) MPI (Xie,* Bahar, and Xing) 2014-2020 NIH - NIDA P30 DA035778
Center for Medical Countermeasures against Radiation (CMCR) Signature-Directed, Sequential Delivery of Radiation Mitigators (PI: Greenberger, UPMC) PI of Comp System Pharmacology Core 2010-2020 NIH-NIAID U19 AI068021
BD2K (Big Data to Knowledge) Center for Causal Discovery (CCD) (PIs: Cooper* and Bahar, Pitt) MPI (Cooper* and Bahar) 2014-2019 NIH-NHGRI U54 HG008540
(*) corresponding PI